The systolic blood pressure intervention sprint trial. Patients with any lvef were included in the trial, but inclusion criteria for patients with hfref required established therapies with acei or arb and bb at optimal or besttolerated doses before randomization unless a contraindication or intolerance was documented. A complete list of the members of the systolic blood pressure intervention trial sprint research group is provided in the supplementary appendix, available at. Jackie bosch at the american college of cardiology. Sprint randomized trial of tibial fracture fixation. In a clinical trial, the investigators must specify inclusion and exclusion criteria for participation in the study inclusion criteria are characteristics that the prospective subjects must have if they are to be included in the study, while exclusion criteria are those characteristics that disqualify prospective subjects from inclusion in the study. The systolic blood pressure intervention trial sprint is a 2arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure sbp to a lower goal than currently recommended will reduce cardiovascular disease cvd risk. Cushman, md chief, preventive medicine, memphis va medical center. Listing a study does not mean it has been evaluated by the u. Ambulatory blood pressure in hypertensive patients with. Whelton, mb, md, msc chair, sprint steering committee tulane university school of public health and tropical medicine, and school of medicine for the sprint research group. Apply jnc8 recommendations and the sprint trial results appropriately in clinical practice.
Bp values and categories in patients with inclusionexclusion criteria of the systolic blood pressure intervention sprint trial from. However, it must be remembered that hypertension canada recommends blood pressure to. Systolic blood pressure intervention trial full text view. Generalizability of results from the systolic blood pressure intervention trial.
Systolic blood pressure intervention trial sprint is an unmasked openlabel randomized controlled clinical trial examining the effect of a high blood pressure treatment strategy aimed at reducing systolic blood pressure sbp to a lower goal than is currently recommended. Sprint randomized trial of tibial fracture fixation the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Effect of intensive blood pressure lowering on left ventricular hypertrophy in patients with hypertension. The systolic blood pressure intervention trial sprint is a 2arm, multicenter, randomized. Heart outcomes prevention evaluation3 american college. Pulmonary artery pressureguided management of patients. The systolic blood pressure intervention trial sprint the sprint study research group abstract. Sprint csr the official site for press releases, photos, video, audio, pr contact information, presskits and more. The sprint trial, funded by the nhlbi arm of the nih and cosponsored by the niddk, nimds and nia, was based on a working group report pdf link from 2007, which identified the question of targeting low blood pressure i. These results thus provide further validation of the 2015 lipid guidelines approach.
Suspected whitecoat hypertension, when all of the following criteria is met. Sprint samantha maples, pharmd pgy1 pharmacy resident. The systolic blood pressure intervention trial sprint. A randomized trial of intensive versus standard blood. The following are criteria for the inclusion and exclusion of patients to the phase i stem cell clinical trial underway at johns hopkins and titled. Systolic blood pressure intervention trial sprint principal results paul k. Ambulatory blood pressure in hypertensive patients with inclusion criteria for the sprint trial. Systolic blood pressure intervention trial sprint protocol version. Tanner rm, hess r, colantonio ld, shimbo d, muntner p. Patients were randomized to intensive bp control targeting sbp sprint methods and results. A randomized trial of intensive versus standard bloodpressure. Systolic blood pressure intervention trial american. Cox proportional hazards regression was used to identify independent predictors of the sprint primary outcome and adverse events. Antihypertensive drug management to achieve systolic blood pressure criteria 12, 17.
Systolic blood pressure intervention trial sprint aha journals. With at least one of the following cv risk factors. Blood pressure variability predicts adverse events and. Submissions from the sprint data analysis challenge on. The systolic blood pressure sbp intervention trial. The sprint inclusion criteria are presented in table 1. Out of a total of 143 sprint challenge submissions, 29 submissions met our inclusionexclusion criteria and were included for analysis online supplementary appendix i.
A randomized trial of intensive versus standard bloodpressure control. Systolic blood pressure intervention trial sprint principal results. The 2015 systolic blood pressure intervention trial sprint studied 9,361 nondiabetic patients. The objective of setting inclusionexclusion criteria is to identify a trial. Generalizability of the sprint results nejm journal watch. Supplementary appendix this appendix has been provided by the authors to give readers additional information about their work. Management of symptomatic orthostatic hypotension see manual of.
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